UNSCHEDULED DNA SYNTHESIS IN MOUSE GASTRIC MUCOSA TREATED WITH BETEL INGREDIENTS | BIONATURE

Following administration of various combinations of betel quid constituents, the induction of unscheduled DNA synthesis (UDS) in the fore gut of inbred Swiss albino mice and C3H (Jax) mice was investigated. To determine cytotoxicity, the effect of the quid components on replicative DNA production was investigated. UDS was induced to a substantial degree by betel leaf, areca nut, lime, tobacco, and two popular brands of Indian chewing mixes. The UDS was lowered when betel leaf was added, but it was greatly raised when tobacco was added. In a study of replicative DNA synthesis, it was discovered that nut extracts, nut extracts with lime, and commercial flavour brands (pan masala) all triggered replicative DNA synthesis. The test substances' genotoxic and cytotoxic potentials provide quantified risk factors, which is especially important given their rising use in Asian countries.

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