Qualitative and Quantitave Determination of Silver in Silverex - Antimicrobial Cream Using Bentonite

The findings in this work reveal that a surface modified electrode approach may be utilised to identify the presence of silver redox active moiety in silverex, a topical broad spectrum antibiotic, in a qualitative and quantitative manner (SC).

The findings show that when a silver-containing topical cream is spin coated over a carbon graphite working electrode surface, the latter takes on the characteristics of an immobilised SC.

The electrochemical signal of silver in SC was greatly improved when bentonite, a clay montmorillonite with octahedral and tetrahedral sites, was employed as the host matrix. Isomorphous substitution of the silver redox moiety in the octahedral layer is thought to cause pre-concentration of the redox active moiety, resulting in increased redox activity. The surface coverage for the silverex topical in the 20gm tube was determined using voltammetric data obtained from a bentonite modified carbon graphite working electrode. According to the statistics, the 20gm silverex ionic gel contained 0.25g silver, or 0.22 percent silver, compared to the manufacturer's standard of 0.2 percent.

The results of scan rate variation investigations reveal that the STC is neither totally surface attached nor has a diffusion regulated redox mechanism.

The p-Aminophenol has been demonstrated to have a considerable impact on the redox characteristics of STC, and it is thought to operate as an electro-catalyst by decreasing the oxidative stress associated with silver oxidation–reduction in SC.

Because the redox characteristics of SC are unchanged by changes in the pH of the supporting electrolyte solution, Protonation-deprotonation equilibrium is not required.

The redox activity of silver in the SC is dramatically suppressed by polyaniline as a host matrix.

Please see the link :- https://globalpresshub.com/index.php/AJPAM/article/view/1499