MARKER DOTS ARE EXPELLED BY ATTENUATION IN HETEROCHROMATIN OF A CHROMATID | BIONATURE

Some chromosomes have been reported to emit marker dots (1.0-2.5), indicating precursors/indicators of chromosomal mutagenesis in some individuals, including cancer sufferers. As demonstrated by varied banding regimens, these are primarily euchromatic (GC rich). Apart from the chromosomal survey, this work relied on the reinvestigation of 110 individuals (out of 605), resulting in the analysis of over 15000 metaphases. The preferred origins of marker dots are telomeres, and the underlying mechanism may include heterochromatic attenuation releasing transposable euchromatin. This is most likely a prelude to progressive heterochromatinisation.

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