INBREEDING AND ITS CLINICAL CONSEQUENCES: A BRIEF REVIEW WITH SPECIAL REFERENCE TO INDIA | BIONATURE

One of the main goals of genetic epidemiology is to discover and quantify risk variables, both environmental and familial. The evaluation and interpretation of familial or genetic risk factors necessitates careful statistical analysis and interpretation. Individual mobility, and thus the movement of their gametes, is usually constrained in most populations. Individuals limited in a certain area are more likely to mate with others nearby, thereby determining the gene combination in future generations. However, in human civilizations, some preferences are always present when choosing a spouse. Social, religious, linguistic, economic, cultural, and territorial considerations all have a role (Timaizumi, 1986). Inbreeding is the genetic result of matings between genetically related individuals who have at least one common ancestor. The distinction between identity of genes through ancestry and identity by nature simplifies understanding of inbreeding. Malecot (1948) observed that a person who is homozygous for a gene has two homologous genes at a certain locus, which are physically identical but not necessarily descendently identical. By nature, this physical identity is referred to as identity. Inbreeding causes a person to be homozygous for genes that are genetically identical. The goal of this study is to determine the extent of inbreeding in India and its potential clinical repercussions.

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