GENETICS, PREVALENCE AND CLINICAL SIGNIFICANCE OF RED CELL ENZYME, GLUCOSE-6-PHOSPHATE ......

A number of metabolic illnesses have been identified and attributed to an enzymatic deficiency in red blood cells. Thus, enzymopathies have grown in importance in clinical medicine in recent years. The discovery that primaquine-induced haemolytic anaemia was caused by an inherited deficiency of glucose-6-phosphate dehydrogenase (D-glucose-6-phosphate:NADP oxidoreductase,E.C.1.1.1.49) in red blood cells (Carson et al.,1956) prompted a flurry of research into the genetic variants of this enzyme in humans and their clinical significance.

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