GENETIC SIGNIFICANCE OF INCREASED FOETAL HAEMOGLOBIN | BIONATURE

Blood samples from over two thousand people were obtained to explore haemoglobin variations. After completing tests on cellogel electrophoretic separations, comparative results on 208 normal/control, 518 gas affected, and 400 tribal people were reported in this work. Gas exposure in Bhopal during the night of December 2-3, 1984, resulted in increased synthesis of HbF (foetal haemoglobin) in the adult population, according to statistical analysis. According to family studies, 27-63 percent of people in the control group, 42.5 percent of people in the tribal group (inbred isolates), and 8% of those who were exposed to gas had higher HbF attributable to parental genes. The fact that such a low percentage of gas-exposed people died instantly and gradually could be attributed to the fact that those who died immediately and gradually would have already had elevated HbF due to heredity and, in gas reaction, synthesised excess foetal haemoglobin. This hypothesis is backed by a statistical analysis of the current data, which shows that differences in the 10% HbF category are extremely significant when compared to both control and tribe groups. The cellogel electrophoresis examination of globin chains was expanded to chosen families, and some of the bands were examined using a computerised Laser densitometer. There are significant indications that the synthesis of -chains has been increased as a result, implying the possibility of mutation that can only be addressed at the molecular level by using recombinant DNA.

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