GENETIC HETEROGENEITY OF APOLIPOPROTEIN E: ITS ROLE IN HEALTH AND DISEASE | BIONATURE

Apollipoprotein E, a key glycoprotein constituent of High Density Lipoprotein and Very Low Density Lipoprotein, is found in the liver, brain, spleen, kidneys, and macrophages, among other organs in the human body. As a result, it's crucial for exogenous and endogenous lipid transport, as well as reverse cholesterol transfer. Its gene has been sequenced and located in the 19 cent-q 13.2 region. At the locus, there is genetic variation in all of the groups investigated so far. Three common alleles have been identified: apoE2, apoE3, and apoE4. The many characteristics linked with lipid levels in individuals have been found to be influenced by phenotypes. The apoE2 allele is linked to decrease cholesterol levels, whereas the apoE4 variant has the reverse effect. As a result, researchers are looking at whether there are any links between various illnesses involving changes in lipid levels and apoE alleles. The apoE4 allele has been identified in the literature as a dose-dependent significant risk marker gene in Alzheimer's disease. The condition with Coronary Heart Disease and Atherosclerosis is not well understood. More research is needed to determine the significance of apoE genetic variability in illnesses of other tissues where it is produced.

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