ALPHA-1-ANTITRYPSIN, TRANSFERRIN AND HAPTOGLOBIN IN SMOKERS AND NON-SMOKERS | BIONATURE

This report includes findings from a study of alpha-1-antitrypsin distributions (o.1-AT). haptoglobin (Hp) and transferrin (Tf) phenotypes, as well as their related serum levels, in 58 patients with chronic airflow limitation (CAL) and a long history of cigarette smoking. The findings were compared to those of 202 normal, healthy persons who had never smoked a cigarette.

There were differences between patients and control subjects in two of the three systems. The patients had a 42 percent rise in mean blood ol-AT concentrations and an infrequency of the PiM3allele with a value of 0.069 compared to 0.032 in the controls.

The mean haptoglobin level in patients was 2.3 times that of controls, with both Hpl-1 and Hp2-phenotypes showing nearly comparable amounts of around 270 mg/100 ml, a finding that contradicts the reported additive impact of alleles Hp1' and Hp2. In contrast, the patients' mean transferrin concentration was lower than that of the control group.

Thus, this study shows that cigarette smoking increases serum alpha-l-antitrypsin and haploglobin levels, which is consistent with previously published findings. An explanation for the increase has been proposed.

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