A Rare Case of Waldenström’s Macroglobulinemia Associated with Hyperviscosity Syndrome | Asian Journ

Waldenström's macroglobulinemia (WM), also known as lymphoplasmacytic lymphoma, is a rare lymphoproliferative illness characterised by bone marrow involvement and monoclonal gammopathy with Immunoglobulin-M. Hyperviscosity Syndrome (HVS) is caused by pathologic changes in the cellular or protein components of the blood, resulting in increased blood viscosity. It is mainly caused by an excess in immunoglobulins, and is hence commonly associated with WM. We present the example of a 62-year-old woman who was previously healthy but was diagnosed with WM and HVS. After a complete diagnostic workup that included a bone marrow examination, immunohistochemistry, serum protein electrophoresis, and a PET-CT scan, the conclusive diagnosis was made. In addition to the classic symptoms of WM, such as anaemia and weight loss, the patient showed indicators of elevated IgM levels.

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