A NEW APPROACH TO GENETIC LOAD | BIONATURE

Inbreeding levels and related congenital abnormalities in each population are used to calculate genetic burden. This "hereditary load" is exacerbated by lethal mutations. However, observations on the effect of inbreeding on mortality have been contradictory. A minor increase in pre-reproductive mortality is related with greater inbreeding when accepted at face value. The traditional formula, the B/A ratio, which is a measure of the number of fatal equivalents per gamete, appears to be off; this variation could be attributable to non-genetic variables. Genetic risks from mutagenic agents in the human environment have been increasing in recent years as a result of their widespread use, whether deliberately or inadvertently. All of these characteristics, both hereditary and non-hereditary or environmental in origin, can be best defined in human populations, not only by congenital deformities, but also by abortions, stillbirths, and other associated parameters such as mean birth rate and inbreeding levels. This study gives data on these characteristics and proposes a formula or approach for estimating a population sample's genetic load. This is calculated as follows: GL = (Mean birth rate X inbreeding level) + Mean abortion and stillbirth.

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